jyhfr custom essays and research papers (1 essays)

Diabetes Mellitus

1905 words/7 pages

DM has been identified which is characterized by a non-immune mediated destruction of pancreatic islet cells and has been termed as Type 1B DM (Eisenbarth McCulloch , 2009 . It is a well established fact that type 1 DM is genetically determined . Several genes have been implicated to play a role in the pathophysiology of type 1 DM including polymorphisms in HLA-DQalpha , HLA-DQbeta , HLA-DR , preproinsulin , the PTPN22 gene , CTLA-4 , interferon-induced helicase , IL2 receptor (CD25 , a lectin-like gene (KIA0035 , ERBB3e , and an undefined...