COMMD6 sequences appear to be highly conserved during evolution , although , in humans , a COMMD6 splice variant is expressed that has not been observed in other organisms , and the predicted N-termini of COMMD6 proteins in higher organisms are significantly smaller than those observed in lower organisms . In fact , COMMD6 in higher vertebrates consists primarily of the COMM domain , indicating that the COMMD is important , and maybe even sufficient , for CO MMD6 function . The interaction between COMMD1 and COMMD6 was abolished by...











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