The impact of the genome project on drug discovery

Evaluating the Implications of the Human Genome Project on ACE Inhibitors

Introduction

Perhaps the best epitome of global medical collaboration is the Human Genome Project . It started in 1990 and has been formally accomplished on April 14 , 2003 - this is about 5 decades since the milestone marked by the discovery of the DNA helix by Watson Crick [1] . Historically , the conceptualization of genome sequencing has been unofficially tackled among scientific circles since the onset of the 1980s . However , it has only been realized in 1988 following the documentation of the National

br Research Council of a research roadmap for genome sequencing and the template organisms that may be utilized for the project [2] . The report of the council has projected that the Human Genome Project would span 15 years and would entail about 2 .7 billion in investment . The project has been earmarked as global , collaborative undertaking . In fact , there have been 20 satellite sequencing offices situated in 6 countries . It is worth noting that 5 such centers in the US and the UK have been most instrumental in pushing forth the project . Moreover , they have allotted about 5 of their cost to addressing ethical , legal , and social implications ' of the scientific investigations being undertaken . Since then , there have been noteworthy commentaries and approaches that have been put forth regarding the Human Genome Project [3-4]

One of the more contemporary and critical facets of the project has been the discovery of ACE-2 inhibitors that may potentially be a more effective palliative for cardiovascular disease . Given this brief background on the Human Genome Project and its prospects for novel drug discovery , it is worth delving further on a review of related literature suggesting the progress made on ACE2 . The potential of ACE2 as illustrated by Human Genome experiments shall be presented in the succeeding sections , following the statement of the problem and methodology

Statement of the Problem

The present study aims to answer the following research question : What is the current status of studies dedicated to the discovery of new ACE 2 inhibitors ? Once a review of these empirical investigations has been accomplished , the prospects of these on the cure of cardiovascular diseases may also be assessed

Methodology

The study is limited to an investigation of secondary data to undertake an extensive review of the available literature on ACE 2 inhibitors and the projects that have been dedicated specifically for them . All empirical investigations from 1990 to the present shall compose the literature review . Once gathered , these studies shall be presented and critically analyzed by theme . An assessment of the implications and prospects of ACE 2 inhibitors shall be made following the critique

Critique of Literature

The Status of the Human Genome Project

The Human Genome Project has been launched in the 1990s , and since then has made milestones in three core areas , namely , 1 ) drafting genetic maps 2 ) determining physical maps and sequencing [5] . All the genetic maps have been identified , encompassing the fullness of the human genome . The same trend...