The immunity evasion of CD8+ Tcells in the Epstein-Barr Virus

THE IMMUNITY EVASION OF CD8 T cells in EBV

The Immunity Evasion of CD8 T cells in the Epstein Barr-Virus (Student name (School Name (Professor 's Name (Class Name

The immunity evasion of CD8 Tcells in the Epstein - Barr virus

Overview

One of the most important functions of the human body 's immune system is to destroy foreign particles that can harm the body such as bacteria and viruses . Basically , this function of the immune system is carried out by various white blood cells called lymphocytes , which include the T-Cell and the

B-Cell . The B-cell 's principal role is to make antibodies that will help fight against pathogens while the T-Cell plays a major role in cell-mediated immunity , which includes the killing of viruses and tumor cells

However , recent studies have shown that there is a certain virus that has the ability to evade recognition by the body 's immune system and therefore , avoid being eliminated by the cell responsible for killing viruses . According to the research article , A CD8 T cell immune evasion protein specific to Epstein-Barr virus and its close relatives in Old World primates , which was authored by Andrew Hislop , Maaike Ressing Daphne van Leeuwen , Victoria Pudney , Danillle Horst , Danijela Koppers-Lalic , Nathan Croft , Jacques Neefjes , Alan Rickinson , and Emmanuel Wiertz and was published by the Rockefeller University Press it was shown through an experiment that cells infected by the Epstein-Barr virus (EBV ) become less susceptible to the CD8 T Cell as it moves through the phase of gene expression

Based on the article , it was discovered that as the EBV-infected cells move through the lytic cycle , which is the type of EBV 's gene expression wherein viral proteins infect human cells to produce virions , are less affected by CD8 T cell recognition , simultaneous with a decrease in the function of the transporter associated with antigen processing (TAP ) and a decrease in the expression of the surface human histocompatibility leukocyte antigen (HLA ) I (Hislop et al , 2007

The cause of this seemingly evasive action of the EBV-infected cells to CD8 T cell recognition was due to the presence of a gene , BNLF2a , which efficiently inhibited antigen-specific CD8 T cell recognition through HLA-A- , HLA-B- , and HLA-C-restricting alleles when it was expressed in target cells in vitro , during the early stage of the lytic cycle (Hislop et al . 2007

In this regard , this will discuss in detail the procedure of this experiment and also explain the significance of decrease of the EBV-infected cells ' susceptibility to CD8 T cell recognition . In addition , the will also review information that are related to the and also give a brief historical background on the Epstein-Barr Virus which is the main point of interest

Background and Related Literature

In to fully grasp the essence and results of the experiment , it is necessary to first review related terms and information that are pertinent to the subject

Epstein-Barr Virus

The virus belongs to the herpes family , which also includes the Herpes Simplex Virus...