compare and contrast sickle anemia and thalassemia

Running Head : Sickle cell anemia and thalassemia

Sickle cell anemia and thalassemia

Inherited blood diseases compared and contrasted

Abstract

Two inherited blood diss - sickle cell anemia and thalassemia - are examined in this work . Causes of these diss are reviewed . Existing forms of thalassemias and sickle cell disease are discussed along with pathogenesis , time and ways of manifestation of these diseases Frequencies of carriers of mutant alleles responsible for pathological conditions compared in the work are considered

Sickle cell anemia and thalassemia are inherited diseases of the blood Both of

these diseases are hemoglobinopathies , which means that hemoglobin is somewhat affected by pathological process Hemoglobinopathies are rather widespread : about 5 of the world 's population are carriers of a gene mutation for autosomal recessive conditions for a hemoglobinopathy (Metcalfe , Barlow-Stewart , Campbell Emery , 2007 ,

. 812

The thalassemias are , according to Weatherall (1997 , a family of inherited diss of hemoglobin synthesis characterized by a reduced output of one or other of the globin chains of adult hemoglobin (p 1675 . Thalassemia may result from one of more than 200 different mutations of genes encoding ? or ? chains of hemoglobin (Weatherall 1997 ,

. 1675 . Spritz Forget (1983 ) discern four groups of thalassemias ?-thalassemias (p . 335 ?- thalassemias (p . 340 ?-thalassemias (p . 341 ) and ?-thalassemias (p . 344 , whereas Weatherall (1997 ) mentions only two major groups of thalassemias ?- and ?-thalassemias (pp . 1676-1677 . Spritz Forget (1983 ) also stated the following

The classical ?-thalassemias are of two general types ?0- and -thalassemia . In homozygous ?0-thalassemia ?-globin chains are...