binding of amyloid-B peptide to catalase and the role vitamin E antioxidant in alzheimers disease.

(Prasad et al , 2002

.507 ) of the disease has been developed (Chong et al , 2005 Prasad et al , 2002

For example , it is estimated that Alzheimer 's disease affects between four to five million of the 31 million Americans above the age of 65 and a large share of this number receives specialised care . Prasad and others also report that almost 50 percent of the American population above 85 years have symptoms of AD . The number of people with AD is expected to almost double by 2025 when the people above 65

years are estimated to reach 51 million . It is also estimated that the annual cost per patient with AD is about 174 , 000 (Chong et al , 2005 ) with the billion (Prasad et al , 2002 . Such is the case everywhere . AD is not localised to any country or region , though it is more prevalent in industrialised countries

Combined with the alarming incidence rate of AD , the inability of scientists and clinicians to present a comprehensive analysis of the condition and develop a treatment or prevention procedure for the disease has further compounded the challenges presented by AD . Most of the facts know about AD has been based on postmortem studies of AD brains . The presence of extracellular senile plaques composed of amyloid-YA peptide aggregates and intracellular neurofibrillary tangles made of abnormal and hyperphosphorylated protein tau have become the hallmark of AD disease , and the loss of memory and cognitive functions its primary characteristics

Role of Oxidative Stress in Alzheimer 's Disease

In explaining the factors that contribute to the onset and progression of the disease , several hypotheses have been presented and investigated however , the inflammatory reaction hypotheses and the oxidative stress hypotheses have been most extensively investigated . Prasad and others pointed out that evidence of inflammatory reactions in...