Wellbutrin

WELLBUTRIN

DISCRIPTION

Wellbutrin is a brand name for bupropion , an atypical and a second generation antidepressant drug of aminoketone class . Its structure is different from tricyclic and other known antidepressant . Its structure resembles that of diethylpropion . The powder is white crystalline and highly soluble in water , it produces sensation of local anesthesia on oral mucosa . Wellbutrin is supplied for oral administration in 200-450 mg per day . Each tablet contains bupropion hydrochloride and some inactive ingredient like cellulose , glycol , talc , and so on . It is produced by Glaxosmithkline pharmaceutics . Depression is

a state in which there is a severe depressed mood for more than 2 weeks ,and loss of interest or pleasure in usual activities accompanied by sleep and appetite disturbances , agitation or lack of energy , feeling of guilt or worthlessness , decreased sex drive , inability to concentrate , and sometimes , suicidal thought or behavior

USAGE

Wellbutrin is prescribed to help relieve major depression . It can be in form of a normal oral Wellbutrin , or in sustained-released tablet form Wellbutrin SR or in extended-released tablet Wellbutrin XR .It is also used in the treatment of seasonal affective dis SAD : episode of depression that occurs in the fall and winter each year . It is also used to treat depressed patient with bipolar dis , like manic-depressive dis and attention deficit dis i .e . more difficulty focusing , controlling action , and remaining still or quiet The drug is usually taken 3 times a day , with doses at least 6 hours apart , the sustained released tablet is usually taken twice a day , with doses 8 hours apart while the extended release type is usually taken once daily usually in the morning , as they can cause insomnia if taken late

The sustained released tablet also appears to be effective as nicotine replacement therapy in recent trials , even in non depressed patients and has fewer side effects

The usual adult dose is 300mg per day , though dosing should begin with 200mg per day at 100mg 2 times daily , it can be increased later to 300mg .The full antidepressant effect of Wellbutrin may not be evident until about 4 weeks of treatment or longer . In patient in whom no clinical improvement is seen at 300 mg , the dose can be increased to 450mg per day at maximum . This is given as 150mg 3 times in a day Treatment should be discontinued in a patient that shows no adequate responds after appropriate period of time

CLINICAL PHARMACOLOGY ?s neurochemical mechanism of its antidepressant effect is still a subject of research , it does not inhibit monoamine oxidase [MAO , but it is a weak blocker of the neuronal uptake of serotonin and norepinephrine . It sometimes inhibits the reuptake of dopamine

The peak plasma of the drug following an oral administration are achieved within 2 hours , followed by a biphasic decline , 6 hours after a single dose the plasma bupropion concentration are approximately 30 of the peak concentration . It has a short half life and thus required more than once a day doses except for...