Translocations of the RARa gene in acute promyelocytic leukemia

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Translocations of the RARa gene in acute promyelocytic leukemia

1 . Kurzrock R , and Talpaz M , Molecular Biology in Cancer Medicine , 2nd edn , ISBN

61 , Informa Health Care , 1999

Kurzrock and Talpaz describe acute promyelocytic leukemia as an abnormal condition genetically characterized by a gene fusion transcript that involves the RARa gene the gene for the retinoic acid receptor alpha located on chromosome 17 and ProMyelocytic Leukemia (PML ) of chromosome 151 . The resultant fusion protein , as Kurzrock and Talpaz clarify retains the

ligand binding domains of retinoic acid receptor alpha in addition to blocking the transcription of the genes necessary for differentiation of the myeloid cells1 . This leads to promyelocutic leukemogensis . Acute promyelocytic leukemia , as indicated by Kurzrock and Talpaz , is a bone marrow malignancy characterized by deficiency of mature blood cells and excess of immature blood cells referred to as promyelocytes . Kurzrock and Talpaz note that there are various signs associated with acute promyelocytic leukemia1 . These include : fatigue haemorrhagic diathesis , and minor infections . Kurzrock and Talpaz bring to our attention that acute promyelocytic leukemia was recognized as a specific subset of acute myeloid leukemia in the early 1950s . Acute promyelocytic leukemia , according to Kurzrock and Talpaz , is a relatively rare condition it comprises of 10 of all acute leukemias1

The work of Kurzrock and Talpaz provides a critical review of the current comprehension of the molecular origin of malignancy . It also comprises of an extended discussion of apoptosis as well as heredity of cancers . Putting...