Summarise the evidence that genetic factors can contribute to type 2 diabetes mellitus (T2D), and the progress that has been made in identifying contributory genes

Running head : GENETIC FACTORS AND TYPE 2 DIABETES

Genetic Factors and Type 2 Diabetes

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Genetic Factors and Type 2 Diabetes

Researchers have over the years worked to identify the genes responsible for causing type 2 diabetes . It is now known that type 2 diabetes is brought by an intricate interplay of genetic factors as well as other agents such as insulin aberrations , environment , high fat breakdown , increased amounts of hepatic glucose and deranged intestinal hormonal secretion as shown in Figure 1 . However , identifying the

genes that cause type 2 diabetes would be a channel to designing drugs that work at molecular level in the regulation of the expression of such genes . This paper presents the genetic evidence in the cause of type 2 diabetes and the efforts that has been in identifying the contributory genes

Genetic factors have been implicated for the cause of a rare form of type 2 diabetes which develops among the Caucasian teenagers known as maturity-onset diabetes in youth (MODY . Research is in progress to identify the genetic cause of type 2 diabetes among the middle-aged Caucasians as MODY is not the type of diabetes associated with obesity which has become widespread (Los Angeles Chinese learning Center , n .d The gene coding for a fatty-acid binding protein 2 (FABP2 ) has been suggested to be responsible for increased levels of unhealthy lipid (triglycerides ) molecules . The defective FABP2 gene has been associated with insulin resistance and obesity among individuals suffering from types 2 diabetes...