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Patent Search

Patent search

US patent no . 7138408

A ) The tile of this patent is : HIV integrase inhibitors pharmaceutical compositions and

methods for their use

Inventors : Kuki Asuo (US Li Xinqiang (US Plewe Michael B (US Wang Hai (US Zhang Junhu (US

Assignees : Aqouron Pharmaceuticals , Inc

Beta-carboline hydroxamic acid compounds represented by formula (I STR00001 is

used in this patent . These compounds and compositions containing those compounds are sued

to inhibit or modulate the activity of HIV integrase enzyme and to treat diseases and

conditions occurring due to HIV

integrase

This patent has 6 claims . These are

1 A compound of formula (lb , EMI28 .0

A pharmaceutical composition , consisting of therapeutically effective amount of at

least one compound according to claim 1 , and a diluent , carrier or vehicle

acceptable pharmaceutically

3 A method of inhibiting or modulating the HIV virus , by contacting the enzyme of virus through one of the compounds in claim 1

4 . A method treating a disease or condition occurring due to HIV virus integrase

enzyme . This comprises of administering therapeutically effective amount of at least

one compound according to claim 1 , to mammals

5 . A method to replicate the treatment given to mammals in claim 4 , for the humans

6 . A method of inhibiting the activity of HIV integrase enzyme by comprising of

contacting said virus with HIV integrase enzyme-inhibiting the amount of compound

according to claim ( US patent 7138408

New Technology

This new technology is titled as : Use of Chemical Compounds to Stimulate the

Endoplasmic Reticulum (ER ) Stress Response in Tumor Cells Causing Tumor Cell Death

In brief , this technology provides a pathway by which specific drugs kill the tumor cells

This pathway is endoplasmic reticulum (ER ) stress response . 2 ,5 dimethyl-celecoxib (DMC

and related compounds trigger the ER stress response and related compounds trigger the ER

stress response and as a result the tumour cells initiate apoptosis and die

The researchers of this technology are : Axel H . Schtznthal , Nicos A . Petasis , Florence M

Hofman , Stan G . Louie and Thomas C . Chen

A patent application for this technology has been d (New technologies

Legal cases

AZT is the brand name of the drug developed by Borroughs welcome for treating AIDS

patients . It was developed with the help of a scientist at the National Institute of Health . It was a

monopoly product and Borroughs welcome obtained the patent for the same Borroughs had not

entirely developed the product on their own . A government scientist , at the National Institute of

Health , Dr .S .Broder , was involved with the development during the very crucial stage of testing

of the drug . Barr laboratories , under an agreement with the government was granted the license

to make this drug against payment of royalty to the government . When two companies , Barr

laboratories and Novopharm applied for license to the food and drugs Administration , to market

the generic version of AZT . The patent holder of AZT , Borroughs Wellcome , now Glaxo

Wellcome , sued these two firms , namely Bar laboratories and Novapharm for patent

infringement

The...

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