PPT

Hypertension Pathology and Treatment Anesthetic Management Hypertension Vascular Disease Systematic and local BP needed to be closely monitored Low pressure causes insufficient organ perfusion , leading to faulty functioning untimely death of the tissues affected In contrast , there was a higher blood flow , in excess of the metabolic demand , provide no benefit . It could induce blood vessel and organ dysfunction and damage (Kumar , 2005 Elevated blood pressure is called hypertension Vascular Pathology of Hypertension (Kumar , 2005 Hypertension Hypertension is a common health problem and is one of the most important risk factors

for both coronary artery disease and cerebrovascular accidents hypertension can lead to cardiac hypertrophy and , potentially , heart failure , aortic dissection , and renal failure It is widely acknowledged that hypertension is a complex , multifactorial disease that has both genetic and environmental determinants Molecular pathways underlying blood pressure variation have been recently elucidated creating possible targets for therapeutic intervention . Nevertheless , the pathogenic mechanisms of hypertension in the majority of affected individuals remain largely unknown Blood Pressure Blood pressure is proportional to cardiac output and peripheral vascular resistance Indeed , the blood pressure level is a complex trait that is determined by the interaction of multiple genetic , environmental , and demographic factors that influence cardiac output and vascular resistance The major factors that determine blood pressure variation within and between populations include age , gender , body mass index , and diet , principally sodium intake Hypothetical Scheme for Pathogenesis of Essential Hypertension (Kumar , 2005 Causes of Acquired and Inherited Forms of Hypertension (Kumar , 2005 Types and Causes...