Factor V Leiden Deficiency

: Factor V Leiden Deficiency

p : language follow grading sheet . See attachment

Components of the Allocation of Points Points Earned

Introduction of the 5

Explanation of How this Healthcare Issue Impacts Residents of Baltimore 5

Relevance of to Current Healthcare Trends , Percentage of Individuals Impacted Regionally and Nationally 5

Current Research Project related to -Personal , Local , Regional State , Federal or Organizational 5

Discussion of pathophysiology , signs and symptoms and diagnostics non-pharmacologic and pharmacologic treatment , including treatment cost that are inexpensive yet effective 30

Supportive resources and recommendations

to assist in achieving disease control or improvement in the disease state 20

Implications for the family 5

Integration of supportive articles , internet sources and research at least ten (10 ) sources 10

APA format , documentation , spelling , clarity 5

Reference Page 5

Posting of information on Blackboard , summary paragraph 5

- Factor V Leiden Deficiency

Factor V Leiden (FVL ) is a condition in which the individual has a greater risk of developing clots within the blood vessels (thrombosis due to inability to deactivate clotting factor V . It is caused due to a change or mutation in the gene responsible for expressing Factor V . The mutation is known as `prothrombin 20210 (FVL , 2007 . This defect can be transmitted to through the genes , and hence this condition may be herditary . Unlike , Factor V deficiency , this condition results in hypercoaguability of the blood (in Factor V deficiency , bleeding is a prime manifestation . In the US , FVL is the most frequent hypercoagubility dis that is hereditary in nature . It is more common in the White Population (about 5 ) rather than the African-American (about 1 .2 (FVL , 2007 . The conditions can develop in homozygous (both the defective genes are inherited from both the parents ) and in heterozygous (only one gene is inherited from either of the parent ) states . However , homozygous expressions of the disease are more severe in terms of thrombosis risk compared to the heterozygosis versions (the risk of thrombosis increases by about 10 times in homozygous compared to heterozygous versions (FVL , 2007

The National Human Genome Research Institute is conducting a lot of Research in the field of Factor V Leiden . Currently , a study is being performed to determine the effect of Factor V Leiden in children . An area in which research needs to be conducted is to study the different genetic mutations of Factor V Leiden . Individuals suffering from thrombosis are frequently studied (NHGRI , 2006

Factor V , which plays a role during clotting , is inactivated by Activated protein C , and this effectively controls clotting and prevent thrombosis within the blood vessels . In Activated Protein C Resistance (APCR , Protein C is not effective in inactivating Factor V , and hence clot formation within the blood vessels occurs . About 95 of APCR cases develop due to inherited Factor V Leiden . Individuals with FVL have a mutated gene which results in production of an Factor V known as `Factor V Leiden , which responds less frequently to APC . The amino acid number 506 is glutamine...