Curcumin modulates eukaryotic initiation factor 2 alpha and phosphoryled eukaryotic initiation factor 2 alpha in human lung carcinoma cell line A549

Curcumin in lung carcinoma

CURCUMIN IN LUNG CARCINOMA

Curcumin modulates eukaryotic initiation factor 2 alpha and phosphorylated eukaryotic initiation factor 2 alpha in human lung carcinoma cell line A549

Curcumin , a phenolic compound from the rhizome of plant Curcuma Longa has

anti-inflammatory , antioxidant and anti-cancer activities (Pillai 2004 . The chemopreventive action could be due to the induction of apoptosis and thereby arrest the cell life cycle . The cellular and molecular changes that curcumin initiated and led to the induction of apoptosis in the human lung cancer cell lines-A549 and

H1299 were investigated . Results found A549 to be p53 proficient and H1299 p53 null mutant . Initially treatment of the cancer cells was done with 0-160 microM for 12-72 hours . The growth of both cell lines were inhibited in a concentration dependent way . In addition , the inhibition of the H1299 cell lines was also time-dependent . Apoptosis was found in both cell lines . After 12 hours exposure to 40microM curcumin , a decrease in the expression of p53 , bcl-2 and bcl-X (L ) was noted (Pillai , 2004 . No change was observed in the Bak and Caspace genes upto a concentration of 60 microM but a decrease in expression was observed after that from 80-160 microM . The induction of apoptosis in the cancer lung cells was independent of the p53 . These results are similar to our study results

The differences are in the period of exposure and the concentration of the curcumin . Our study had an exposure of 96 hours to while the concentration of cucurmin...