Chemical Biology Proposal

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http /science .calm .wa .gov .au /cswajournal /4-3 /139-144 .pdf

Running Head : CHEMICAL BIOLOGY PROPOSAL A Search for Biologically Active Compounds in Acacia species Student Name : Student ID : Course Title : Course ID : Professor Name : Submission Date :Title A Search for Biologically Active Compounds in Acacia speciesAbstract Acacia species are among the large number of plants that have long been regarded sources of biological activity . This study is guided by the indigenous use of Acacia species as sources of medicine , which led to the use of front-line bioassays . All of the species tested exhibited some form of biological activity . An Acacia species is expected to demonstrate the most promise as a source of novel biologically active compounds exhibiting activity at very low concentrations . Extracts from Acacia species will be screen using two frontline bioassays . These will be the brine shrimp lethality test and the crown gall tumor assays to determine if any of the species are biologically active . Some Acacia species will show promise as anti-tumor activity when it will be use in the Brine Shrimp Lethality Test (BSLT ) and Crown Gall Tumor Assay (CGTA . All of the species that will be screen in this study will be worthy of further evaluation . The bioassays that will be use in this study are good examples of front-line bioassays . All of the tests that will be use in the study fulfill the criterion , which defines a good test . Background introduction The search for novel biologically active compounds has intensified over the years , with many industries ranging from agriculture to medicine interested in finding chemicals useful to them . The use of plants and other organisms as sources of medicinal agents has occurred throughout of the human species history (Latz , 2005 Moran , 2002 . Traditional health care practices have universally recognized that the mind and body are intrinsically linked by the core belief that to prevent ill health there is a need to maintain a balance with Nature 's life force . Although work investigating the medicinal qualities of Native American plants is limited , interesting biochemical activities have been reported (Lassak and McCarthy , Barr , 1992 Latz , 1995 Low , 1990 . A number of different of different compounds that exhibit some type of biological activity have been isolated including monoterpenes , sequiterpenes , flavones and iridoid glycosides (Syah , 1997 . Little is known about the biological activity of Acacia species . Barr (1993 ) and Seigler (2003 ) have reported that a number of Acacia species contain secondary metabolites that are known to exhibit biological activity . The main aim of this study is to search for...