Angiogenesis Inhibition as a Treatment for Cancer

Angiogenesis Inhibition as a Treatment for Cancer

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INTRODUCTION

In United States and other developed countries , one of the leading causes of morbidity and mortality is cancer . The estimated number of deaths due to cancer in United States during the year 2007 is 559 ,650 1 The dilemma caused by cancer brought about the intensive research efforts to come up with treatments and preventive measures to combat this disease . Recognition of the role of

angiogenesis in the formation growth , and metastasis of cancer resulted to the utilization of inhibitors as therapeutic regimen

Angiogenesis is the process of blood-vessel-formation from already present capillaries . This process is a normal during embryo development for circulatory system formation , in the process of wound healing , and in the uterus during menstruation . The construction of vessels to convey blood that carries water , nutrients , and oxygen is necessary for the continuous nourishment of body cells 1

Angiogenesis is a significant mechanism in the pathology of various diseases like cancer . The new blood vessels will provide the cancerous cells with oxygen and nutrients that will support its development and serve as vehicle for the cancerous cells to propagate in other areas of the body 2 . Therefore , angiogenesis which is usually beneficial to the body in its normal state becomes a vehicle for cancer and adds to the pathological process of the disease in reaching other healthy cells

Since angiogenesis is essential in the...