Adrenoleukodystrophy

Involvement of Neuroendocrine 1

Running Head : INVOLVEMENT OF NEUROENDOCRINE

The Involvement of the Neuroendocrine System

In the Disease Process of Adrenoleukodystrophy

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Involvement of Neuroendocrine 2

Abstract

The nervous system and the endocrine system perform integrated functions required to maintain homeostasis . Abnormalities in the regulation of hormones and transmission of nerve impulses may lead to a number of disorders such as adrenoleukodystrophy . Adrenoleukodystrophy is a disease characterized by the abnormal accumulation of very long

chain fatty acids (VLCFA ) predominantly in the white matter of nervous tissues , the adrenal cortex and the spinal cord . These fatty deposits lead to demyelination of nerve fibers and damage to the adrenal cortex leading to progressive and fatal disability and death . Although there is no known cure for this disorder , there are three basic approaches to treatment that are currently under investigation - diet modification immunosuppression , and bone marrow transplantation . Among the three bone marrow transplantation has shown to be most effective in halting the progression of the disease

Involvement of Neuroendocrine 3

Adrenoleukodystrophy : A Disease of the Neuroendocrine System

The synergistic activity of bodily functions occurs as a result of two body systems working closely with each other , the nervous system and the endocrine system . These two systems are integrated to regulate body functions and are sometimes referred to as the neuroendocrine system (Bhise , Yadav Burkul , 2007 . The neuroendocrine system is composed of the hypothalamus , pituitary gland , the autonomic nervous system , the central...